The advance screening of The Case Study of Vanitas (Vanitas no Carte) revealed that the anime will premiere on July 2. The staff also reported that the series will consist of two parts (each quarterly).

Tomoyuki Itamura (Nisemonogatari, Owarimonogatari, Tsukimonogatari) is directing at BONES, and Deko Akao (Noragami, Snow White with the Red Hair) is in charge of the series' scripts. Yoshiyuki Ito (Concrete Revolutio, Carole & Tuesday) is the character designer and chief animation director. Yuki Kajiura (Demon Slayer, Sword Art Online, Fate/stay night: Unlimited Blade Works, Pandora Hearts) is composing the music. sasanomaly performs the opening song "Sora to Sora" (Sky and Sky).

Yen Press describes the first volume as follows:

Rumors surrounding the Book of Vanitas, a clockwork grimoire of dubious reputation, lure Noé, a young vampire searching for a way to save a friend, to Paris. What awaits him in the City of Flowers, however, is not hours of idly strolling the sidewalks or rummaging through dusty bookshops in search of the tome. Instead, his quarry comes to him... in the arms of a man who claims to be a vampire doctor! Will Noé be drawn into a conflict that threatens the peace between humans and vampires? Will he share his fate with the curious and slightly unhinged Vanitas and his quest to save the vampire world?