Sir Christopher Lee, renowned for his extensive career in live-action film, also made significant contributions as a voice actor in animation and video games, bringing his commanding presence and distinctive deep voice to a variety of roles. One of his notable forays into anime-style animation was in the 1979 Japanese-American stop-motion film Nutcracker Fantasy. In this production, Lee voiced the mysterious Uncle Drosselmeyer, a clockmaker and doll maker whose gift of a nutcracker to his niece Clara sets the story in motion. Demonstrating his vocal range, he also provided voices for several other characters in the film, including a Street Singer, the Puppeteer, and the Watchmaker, and even performed songs for the soundtrack.

Beyond this specific role, Lee's voice acting career spanned numerous animated features and video games, often lending his gravitas to fantasy and villainous characters. He voiced King Haggard in both the English and German dubs of the 1982 animated film The Last Unicorn, showcasing his multilingual abilities. He collaborated multiple times with director Tim Burton, providing the voice for Pastor Galswells in Corpse Bride and the Jabberwocky in Alice in Wonderland. Lee also found a recurring place in the video game world, most prominently as the voice of Ansem the Wise in the popular Kingdom Hearts series, appearing in Kingdom Hearts II and Kingdom Hearts 358/2 Days.

His deep association with the fantasy genre continued in animation through his work on adaptations of Terry Pratchett's novels, where he voiced the character of Death in the animated versions of Soul Music and Wyrd Sisters. He later reprised his iconic live-action role of Saruman for the 2024 anime film The Lord of the Rings: The War of the Rohirrim. This was achieved not through new recording but by carefully reusing and repurposing archived audio of his voice from his time working on The Hobbit film trilogy, a decision made with the consent of his estate to maintain character consistency. This extensive body of work across different media highlights a dedicated and impactful voice acting career that complemented his legendary on-screen presence.