Melissa Medina is a professional voice actor, director, producer, and singer known for a wide vocal range and work across animated series and video games. Their career path is distinctive, beginning with training as an opera singer and in Broadway and jazz styles before shifting to a role in healthcare technology as an IT product manager and data scientist. They eventually returned to performance, now applying their voice in both English and Spanish to animation, video games, commercials, and other media.

In anime, Medina is recognized for voicing the character Wa Lin in the long-running series Kingdom. Their voice work is also prominent in the video game industry, with a wide range of roles in major franchises. These credits include Yuel in Granblue Fantasy: Versus, various characters in the Borderlands, Fallout, and Elder Scrolls series, and the role of Heta Kol in Star Wars: The Old Republic: Legacy of the Sith. Additional game credits include Lettie in Warframe, Arknights, MechWarrior 5, and Billie Bust Up.

Beyond performance, Medina has expanded their role in the industry as a co-founder of Scary Good Studio, a company that provides full audio production services for games and animation. They also work as a voice director and have served as a brand voice for companies like JCPenney. Their background in data science informs an approach to the industry that bridges technology and artistry, and they are noted for advocating for creator rights and industry transparency.