Masakazu Ishiguro is a Japanese manga artist known for creating series that blend slice-of-life comedy with science fiction and mystery elements. He was born in Fukui Prefecture on September 8, 1977, and cites childhood influences such as Fujiko Fujio's Doraemon and the film Akira as major inspirations for his work. He graduated from Osaka University of Arts in 2001.

Ishiguro made his professional debut as a manga artist in 2000 with the one-shot Hero, which won the Afternoon Shiki Award prior to his graduation. He is best known as the original creator of two manga series that have been adapted into anime: And Yet the Town Moves and Heavenly Delusion.

And Yet the Town Moves, known in Japanese as Soredemo Machi wa Mawatteiru, was serialized in the magazine Young King OURs from March 2005 to October 2016, spanning sixteen collected volumes. The story follows Hotori Arashiyama, a high school girl who works at a maid café in a shopping district, and blends mundane daily life with occasional surreal or paranormal events. The series received a twelve-episode anime television adaptation produced by the studio Shaft, which aired from October to December 2010.

Heavenly Delusion, known in Japanese as Tengoku Daimakyō, began serialization in Kodansha's Monthly Afternoon magazine on January 25, 2018. Set fifteen years after a catastrophic disaster, the story follows a boy named Maru and a girl named Kiruko as they travel through a ruined Japan in search of a place called "Heaven," while simultaneously depicting the lives of children living in a mysterious, isolated facility. The manga received a thirteen-episode anime adaptation produced by Production I.G, which aired from April to June 2023.

Beyond these two major works, Ishiguro has created a number of other manga series, including Agape, Skygrazer, Nemurubaka, and Mokuyōbi no Furutto, which began publication in 2009 and is still ongoing. His creative identity is defined by a versatility across genres, often constructing narratives that appear to be simple comedies or slice-of-life stories before introducing intricate mysteries, science fiction concepts, and suspense. In an interview, he has stated that his work is influenced by his interest in artificial intelligence, Japanese mythology, and fundamental questions about what it means to be human. He has also noted that the 2013 concept art he drew for a magazine cover served as an early inspiration for what would later become Heavenly Delusion.

And Yet the Town Moves has received significant industry recognition, winning an Excellence Award at the 17th Japan Media Arts Festival in 2013 and the Seiun Award for Best Comic in 2018. Heavenly Delusion topped the Kono Manga ga Sugoi! guidebook's list of the best manga for male readers in 2019 and won the Daruma Award for Best Screenplay at the Japan Expo Awards in 2023.