Vanessa Williams provided the voice for the character Hisako in the English-language dubbed version of the Studio Ghibli animated film When Marnie Was There. This 2014 film, directed by Hiromasa Yonebayashi, features a prominent cast for its English adaptation, including Hailee Steinfeld and Kiernan Shipka in the lead roles. In the story, Hisako is an older woman who paints pictures and is someone the protagonist, Anna, meets during her stay in the countryside. Multiple sources, including the film's credits on IMDb and product listings, confirm Williams's involvement in this specific role.

Beyond this credit, publicly available and verifiable information does not establish Vanessa Williams as having a significant body of work specifically within the genre of anime voice acting. Her extensive and well-documented career encompasses work in live-action film, television, music, and stage, with some additional credits in voice acting for other forms of animation. However, recurring collaborations with specific anime directors, studios, or a list of major anime voice roles beyond the single instance of When Marnie Was There are not evidenced in the accessible information. Consequently, a comprehensive profile of Vanessa Williams specifically as an anime voice actor cannot be assembled from the available, reliable information.