Isa Di Marzio was an Italian actress and voice artist whose career spanned over five decades, during which she became a prominent figure in radio, theater, and the dubbing industry. Born Luisa Malcotti in Turin on April 7, 1929, she began her career as a child actress on radio before transitioning to a prolific career in voice acting.

Her early work was deeply rooted in Italian radio, where she demonstrated a versatile and brilliant voice in popular variety shows and radio dramas from the 1940s through the 1960s. This experience laid the foundation for her later success in dubbing, a field in which she became especially active from the 1980s until her death. In addition to voice work, Di Marzio was also a singer, notably performing the Italian theme song for the television series Pippi Longstocking, and she appeared in a few films and on stage, including performances in productions directed by Giorgio Strehler and in musical comedies by Garinei and Giovannini.

As a voice actress, Isa Di Marzio lent her voice to an extensive range of characters in Italian-dubbed versions of international animation and live-action series. In the realm of anime, she is recognized for voicing the title character in The Fantastic Adventures of Unico, a role that connects directly to the user's query. Her other significant anime roles include Arthur Foster in Captain Tsubasa (known in Italy as Holly e Benji, due fuoriclasse), Obaba in the initial episodes of Ranma ½, and multiple characters in Lamù la ragazza dello spazio (Urusei Yatsura), such as Ten and the second voice of Lum's mother. She also provided voices for Spank in Hello! Spank and Flappy in Juny peperina inventatutto.

Her work extended far beyond anime to encompass a vast array of Western animation and live-action dubbing. Di Marzio was the first Italian voice of Miss Piggy in The Muppet Show, Dixie in Pixie and Dixie, and Woody Woodpecker. She was also one of the early voices for Jerry Mouse and Mammy Two Shoes in Tom & Jerry and voiced Wilma Flintstone. In live-action television, she was particularly known as the voice of Louise Jefferson in both All in the Family and The Jeffersons, and as the first voice of Aunt Assunta in The Nanny. Her film dubbing credits include Mrs. Potts in Beauty and the Beast and Esme Hoggett in Babe.

Throughout her career, Di Marzio collaborated frequently with other notable figures in Italian dubbing and entertainment. She often worked alongside voice actor Elio Pandolfi, with whom she formed the animated duo Toto and Tata for a famous series of Carosello advertisements for Motta in the early 1960s. She also shared the microphone with colleagues like Rita Savagnone in radio variety shows. Her later years saw her directing the dubbing for the animated series Isidoro.

Isa Di Marzio passed away in Rome on January 10, 1997, at the age of 67, while still actively working on dubbing projects such as The Nanny and Roseanne. Her legacy is that of a highly versatile and hard-working artist whose distinctive voice became familiar to generations of Italian viewers through her vast body of work in animation and television.