Simon Issacson is a professional name used by the American voice actor Simon Prescott, who has built an extensive career spanning several decades in the anime industry. His work is primarily known through English-language dubs of Japanese animated series and films, where he has provided voices for a wide array of characters.

Born in May 1936, Prescott's career in voice acting began to flourish with the growth of the anime market in North America. He is often credited under various names, including Simon Isaacson, Sy Prescott, and Ben Isaacson, which were sometimes used for non-union productions. His body of work demonstrates a prolific period of activity, particularly from the 1980s through the 2000s. As the user query highlights, one of his roles under the Simon Issacson alias is Hoi Hoi in the 1998 film Catnapped! The Movie.

His voice is featured in many notable and influential anime titles. Some of his most recognized roles include Chief Nakamura in the landmark film Ghost in the Shell, a role he performed under the name Ben Isaacson. He also voiced Dr. Laughton in the film Metropolis and Aritomo Yamagata in the beloved series Rurouni Kenshin. For the long-running Gundam franchise, he contributed voices to several entries, including as Degwin Sodo Zabi in the compilation Mobile Suit Gundam movies, Captain Eiphar Synapse in Mobile Suit Gundam 0083: Stardust Memory, and Meitzer Ronah in Mobile Suit Gundam F91. In the series Cyborg 009: The Cyborg Soldier, he was the voice of Professor Isaac Gilmore across all 46 episodes. Other prominent credits include roles in Cowboy Bebop, Paranoia Agent, Samurai Champloo, and Street Fighter Alpha: The Animation.

Throughout his career, Simon Issacson frequently collaborated with a consistent group of fellow voice actors based in the Los Angeles area. His name appears alongside actors such as Steve Blum, Kirk Thornton, Richard Cansino, and Doug Stone in the credits of numerous dubs produced during that era. This points to a regular pool of talent that worked together on many projects for studios like Animaze and others handling English localizations.

His notable achievement lies in his contribution to the foundation of English-dubbed anime. By voicing characters in some of the most critically acclaimed and popular titles to be brought to the West, he helped shape the voice of anime for an entire generation of viewers. His work spans a wide variety of genres, from science fiction classics to historical dramas and comedies, demonstrating his versatility and lasting presence in the industry before his apparent retirement from voice work around 2008.