Sissa Afonso is a Portuguese voice actor known for her work in dubbing animated series and films for Portuguese audiences. She was born in Porto, Portugal.

Afonso has contributed her voice to a wide range of anime and animated series. One of her notable roles in anime is providing the Portuguese voice for the protagonist Perrine in the classic series The Perrine Story. Her other anime dubbing work includes the role of Rei Ayanami in the Portuguese version of Neon Genesis Evangelion, as well as contributions to series such as Vandread and the sports anime Captain Tsubasa, known in Portugal as Campeões: Oliver e Benji, where she voiced characters like Patty Nakazawa.

Beyond anime, her portfolio includes voice work in various other animated productions. She voiced characters in children's series such as Ruca (as Rosita), Babar (as Flora in seasons four and five), and Wow! Wow! Wubbzy! (as Buggy, Huggy, and Cintilante). She also contributed to shows like Animalia, Arthur, and the animated series The Incredible Spider-Man. In addition to series, her film dubbing credits include The Proud Family Movie and Bratz: Genie Magic.