Denise Poirier is an American actress recognized for her work in voice acting, particularly in animated series and English dubs of anime productions. She is best known for providing the voice of the titular character in the iconic MTV animated series Æon Flux.

In the realm of anime, Poirier voiced the character Shizuka Tachibana in the 1997 English language version of the animated film Twilight of the Dark Master. Her other prominent voice roles in anime include Sonia, also known as Queen Bee, in the 1998 Urban Vision Entertainment dub of Golgo 13: Queen Bee and Cassandra in the 2003 series Reign: The Conqueror. She also lent her voice to the character Carmila in the Vampire Hunter D video game.

Beyond anime, Poirier's voice acting portfolio includes roles in the HBO animated series Spawn and an episode of the anime-inspired series Pet Shop of Horrors. Her career also encompasses live-action television, with guest appearances on popular shows such as Seinfeld, Frasier, and 3rd Rock from the Sun. In 2015, she voiced the character known as The Hole in the film Deep Dark.