Mitsuha Sakisawa is a creator known for originating manga works, primarily within the romance and ecchi genres. Sakisawa is credited as the story author for the manga series Ero Lover, which was published from 2008 to 2012 and spans three volumes. The series, which features art by illustrator Nekousa, is set in a school dormitory where male and female students live together for the purpose of having children, following the developing relationship between the protagonist Miya and the dorm leader Heiji.

In March 2019, Ero Lover received an anime adaptation produced by Asura Film for Production I.G's Anime Beans smartphone application. The anime debuted on the platform on March 22, 2019, with sound production handled by Cloud22. The cast for the adaptation included Marie Miyake as Miya Nakanishi and Ryuichi Kijima as Heiji Kozawa. The original work was produced in cooperation with highstone, Inc.

Beyond Ero Lover, Sakisawa is also credited as the original creator for the manga series Eroraba, with art provided by Zero Ran. The third volume of Eroraba was released by publisher Takeshobo on November 25, 2012. Sakisawa's creative role in these projects is consistently defined as providing the story or original concept, working in collaboration with separate illustrators. The manga Ero Lover has been noted for achieving significant download numbers as a mobile comic, with the series reportedly surpassing ten million downloads. The anime adaptation of Ero Lover has been classified in some records with genre labels including romance, ecchi, and hentai.