Adrian Alphona is a Filipino-Canadian comic book artist known for his work in the American comic book industry, primarily for Marvel Comics. He gained prominence as the co-creator and primary artist for the series Runaways, which he developed with writer Brian K. Vaughan. The series, launched in 2003, became a critical success and established Alphona's reputation for depicting teenage characters with a distinctive sense of style and realism.

Alphona’s career includes work on several other Marvel titles. He provided art for Captain Britain and MI 13 in 2009 and later worked on Uncanny X-Force. After a period away from comics, he returned to prominence as the artist for the 2014 relaunch of Ms. Marvel, written by G. Willow Wilson. This series, which introduced a new teenage Muslim American heroine named Kamala Khan, was a landmark publication for Marvel and received widespread acclaim.

Alphona’s artistic identity is characterized by a strong grasp of human anatomy and contemporary fashion, which lent authenticity to the teenage protagonists in Runaways and Ms. Marvel. His work on Runaways involved designing the definitive looks for the main cast, with characters often changing outfits across different story arcs, a detail that contributed to the series' realistic feel. He is known for being a private individual who has given few interviews.

Within the comic book industry, Alphona’s work has been recognized with several accolades. He was a recipient of the Harvey Award for Best Series for Runaways in 2006. His work on Ms. Marvel earned him a Hugo Award for Best Graphic Story in 2015, a Joe Shuster Award for Best Artist in 2015, and the Series Award at the Angoulême International Comics Festival in 2016.