Mary Elizabeth Winstead, primarily known for her extensive work in live-action film and television, has a limited but notable presence in the field of anime voice acting. Her most prominent and defining role in the medium is voicing Ramona Flowers in the Netflix anime series Scott Pilgrim Takes Off, which premiered in 2023.

This role represents a unique continuation of her association with the character. Winstead originally portrayed Ramona Flowers in the 2010 live-action film Scott Pilgrim vs. the World. For the anime adaptation, she, along with the entire principal cast of the film, returned to voice their respective characters, marking a significant and highly publicized reunion. This casting choice was a central feature of the series, bridging the gap between the live-action and animated interpretations of the Scott Pilgrim universe.

In discussing her experience transitioning from live-action to voice acting for Scott Pilgrim Takes Off, Winstead noted the unique opportunity to revisit a character she had played over a decade earlier. She brought a new perspective to the role, incorporating the life experience she had gained in the intervening years to inform her vocal performance. The series itself explores themes of growth and revisiting the past, a concept Winstead found resonant with her own experience of returning to the character at a different stage in her life.

Aside from her starring role in Scott Pilgrim Takes Off, publicly available and widely recognized information about other significant anime voice acting credits for Mary Elizabeth Winstead is sparse. Her filmography is overwhelmingly dominated by live-action performances, with her voice work in animation primarily consisting of this single, high-profile project. Therefore, her career as an anime voice actor is defined almost entirely by this one performance, which stands out due to its connection to her iconic live-action role and the meta-circumstances of the entire original cast returning for an animated series.