Aubrey Plaza has built a career in voice acting that complements her on-screen work, bringing her distinctive deadpan delivery to a range of animated characters. Her voice acting career, while not as extensive as her live-action work, includes several notable roles in both anime and western animation.

Plaza's most prominent anime role is that of Julie Powers in the Scott Pilgrim franchise. She first portrayed the character in the 2010 live-action film Scott Pilgrim vs. the World. Over a decade later, she returned to the role for the 2023 Netflix anime series Scott Pilgrim Takes Off, reprising her voice performance as the acerbic and socially connected Julie. This reprisal represents a significant through-line in her career, bridging her early film work with a major anime production.

Another significant anime voice credit is her role as Eska in the second season of the acclaimed animated series The Legend of Korra. This role placed her within the universe of a beloved anime-influenced series, further establishing her presence in the voice acting world.

Beyond these specific anime roles, Plaza has an extensive body of voice work in animation that showcases her versatility. She voiced the character Claire Wheeler-Worthington in the Pixar film Monsters University in 2013 and later returned to the role for the second season of the Disney+ series Monsters at Work in 2024. Her television voice credits also include a guest appearance as Nocturna, a goth teen fish, in an episode of the long-running series SpongeBob SquarePants. She also served as an executive producer and provided a voice role in the animated series Little Demon, which premiered in 2022.

Plaza has also been attached to upcoming animated projects. She was cast as the voice of Brain the Spider in the animated feature film The Ark and the Aardvark, a project that has been in production. While the release status of this film is not confirmed, it indicates her continued engagement with voice acting.

Throughout her career, Plaza's voice roles often leverage her signature deadpan and darkly comedic sensibility. This has made her a recognizable and sought-after talent for characters that require a sardonic or offbeat tone. While she does not have a frequent, publicly noted recurring collaboration with a specific anime director or studio, her body of work demonstrates a consistent and successful integration of voice acting into her broader career. Her achievements in this area are part of a larger career that has earned her critical recognition, including nominations for Primetime Emmy Awards and a Golden Globe Award for her live-action performances, as well as a Screen Actors Guild Award for her ensemble work in The White Lotus.