Mpilo Jantjie is a voice actor known for work in animated television and short films. Jantjie came to prominence by providing the speaking voice for the lead character Aau in the 2023 animated short film Aau's Song, which serves as the series finale for Star Wars: Visions Volume 2. The stop-motion short, produced by the South African studio Triggerfish, tells the story of a young girl whose singing voice has a unique effect on kyber crystals in the Star Wars universe. For this role, Dineo Du Toit provided Aau's singing voice while Jantjie was responsible for the character's spoken dialogue.

Beyond the Star Wars franchise, Jantjie is a cast member in the animated series Zizi and Hannibal. Across multiple volumes of the show, which follows the adventures of a young girl named Zizi and her hippo friend, Jantjie is listed as a voice actor alongside performers Sanda Shandu, Tankiso Mamabolo, and Ashley Dowd. The series aired as a television program starting in 2021 before later being released on DVD.

Additional noted work includes a role in an upcoming television movie titled Coco the Money Bunny. Jantjie has collaborated with the same group of voice actors on multiple projects, particularly appearing alongside Sanda Shandu and Tankiso Mamabolo in the Zizi and Hannibal series.