Harvey Guillén has developed a significant career as a voice actor in animation, with his work increasingly intersecting with the anime medium. He is known on screen for his lead role as Guillermo de la Cruz on the FX comedy series What We Do in the Shadows, which earned him multiple Critics Choice Award nominations and made him the first queer Latinx actor nominated in that category. This success has transitioned into a robust voice-over career, where his versatile vocal range has made him a sought-after talent for animated projects.

Guillén's most direct contributions to anime-style production come from his involvement in the Star Wars: Visions anthology series. He provides the voices for two characters in Volume 3 of the series, performing the roles of BILY and Darth Bear. Star Wars: Visions is an anime-inspired project that collaborates with various renowned Japanese animation studios, placing Guillén's work within the sphere of global anime-influenced storytelling.

Beyond this specific credit, Guillén has voiced a wide array of characters in animated series and films that appeal to fans of animation and genre storytelling. His notable voice roles include Perrito in the Academy Award-nominated feature Puss in Boots: The Last Wish, Odie in The Garfield Movie, Nightwing in the adult animated series Harley Quinn, and Vassago in Helluva Boss. He has also performed the role of Gary Prince in Adventure Time: Fionna and Cake. His extensive television voice work includes Funny the Magic House in Mickey Mouse Funhouse, Square in Shape Island, a recurring role in Netflix's Human Resources, and Pelpel in Kung Fu Panda: The Dragon Knight.

While his career demonstrates recurring collaborations with major animation studios such as DreamWorks, Disney, and Warner Bros., the search results do not specifically identify a pattern of repeated collaborations with specific Japanese anime studios or directors. His work remains notable for its range across different genres and formats within the voice-acting industry. Guillén has earned recognition for his performances, winning two Imagen Awards and a GLAAD Media Award, and his work in Puss in Boots: The Last Wish was part of an Academy Award-nominated production.