Mitsue Yamazaki is a Japanese animation director and storyboard artist. She is known for her work on several popular television anime series and made her debut as an original creator with the 2025 anime ZENSHU. Yamazaki was born in 1980 and began her career in the animation industry in 2002 as a production assistant at the studio MADHOUSE. She later moved to the studio NOMAD before becoming a freelance director, working with studios such as Brain's Base, MAPPA, and others.

Yamazaki made her directorial debut in 2013 with the series The Eight Dog Chronicles, for which she also served as series composition writer and wrote scripts. She is widely recognized for directing the acclaimed comedy series Monthly Girls' Nozaki-kun in 2014. Her other notable directing credits include Tada Never Falls in Love (2018), How Heavy Are the Dumbbells You Lift? (2019), and Sleepy Princess in the Demon Castle (2020). She has also worked extensively as a storyboard artist and episode director on numerous other series, including Mawaru Penguindrum, Noragami, and Attack on Titan The Final Season.

In 2025, Yamazaki took on the role of original creator, director, and storyboard artist for ZENSHU., an original anime series produced by MAPPA. The series, which aired from January to March 2025, is an isekai story about a prodigal animator who is transported into the world of her favorite childhood anime film. She shares the creation credit for the series with writer Kimiko Ueno and the studio MAPPA.

Yamazaki has been noted for strengths in character description and dialogue, and for creating a dramatic atmosphere, often putting emphasis on directing the mood and facial expressions in static scenes. She has cited directors Matsuo Kou and Takayanagi Shigehito as her mentors. Through her work as a director on multiple popular comedy and character-driven series, and as the co-creator of ZENSHU., Mitsue Yamazaki has established herself as a significant directorial talent in the anime industry.