Nadeen Lightbody is a film, television, and voice over actor born in Toronto, Canada, to parents of Jamaican descent. Her first role was Shyanne in the 2007 series The Kink in My Hair. She later co-starred on the Discovery Channel documentary series Natural Born Dealers, appearing as herself. Lightbody was featured in the short film Avalanche, playing Janice, a middle-aged mother and homemaker concerned for her son. The short premiered at the New Orleans Film Festival in 2014 and was directed by Thyrone Tommy.

In voice acting, Lightbody is known as the voice of Amphibia, a sea-creature character on the Cartoon Network series Monster Beach, which has aired in Australia and Asia. She also played the role of Robotnik Agent in the 2020 film Sonic the Hedgehog. Additional live-action roles include a Loan Officer in the television movie Deliver by Christmas, Agent Number Four in NarcoLeap, and a Reporter in the series The Flash.