Natalie Moon is a classically trained, bidialectal actor originally from England, who studied at the Oxford School of Drama. She is currently based in Vancouver, British Columbia, where she works extensively in the North American film and television market.

While Moon has worked on projects within the broader speculative fiction genre, her role in the 2017 live-action film adaptation of the manga and anime series Death Note is a notable credit. In the Netflix film Death Note, directed by Adam Wingard, she portrayed the British News Anchor. It is important to clarify that this is a live-action performance and not a voice acting role in an animated series.

Beyond this, her career spans numerous guest starring roles in major television series. In the superhero genre, she has appeared in the DC Comics-based series The Flash as Inspector Jane and as Erica Del Portenza in Superman & Lois. Her other television credits include a role as Mary-Jane Constantine in DC's Legends of Tomorrow, as well as appearances in the Netflix series Travelers, the CBC drama Allegiance, the Hallmark series Chesapeake Shores, the HBO Max series Space Force, and the Hulu show Motherland. Her film work includes a role in the supernatural thriller Brahms: The Boy II.

Moon is also a writer, director, and producer, having created the short film One Day, in which she also starred and which was featured at film festivals. In addition to her on-screen work, she works as a private acting coach and accent and dialect teacher, having been a resident voice and acting teacher at several theatre schools in Vancouver.