Kate Bond is known for her work as a voice actor in animation, with her most prominent role being the character Casey in the Transformers franchise. She provided the English voice for the character Crasher Casey, the tough and talented operator of the Mechanosaurus vehicle, in the series Transformers: Robots in Disguise, which aired from 2014 to 2017. The character is a fearless and competitive five-time winner of the Crown City Grand Prix.

Beyond her voice work in animation, Bond has an extensive career as a screen actor. She landed her first on-screen role opposite Tim Roth in the Fox drama Lie to Me. She subsequently worked with Jim Caviezel on the CBS series Person of Interest and appeared with Oprah Winfrey and Rose Byrne in the HBO film The Immortal Life of Henrietta Lacks. She also produced and starred in the web series Girls Series. Starting in 2017, Bond began a recurring role on the CBS series MacGyver. In addition to her acting work, some of her writing has been published in Playboy.