Wil Wheaton has established a diverse career as a voice actor in anime, bringing his distinctive vocal presence to several notable English-language dubs. His entry into anime voice work came after decades of high-profile live-action roles, including his breakout performance as Gordie Lachance in the film Stand By Me and his well-known portrayal of Wesley Crusher on Star Trek: The Next Generation. Wheaton began voice acting early in his career, providing the voice for the young mouse Martin Brisby in the animated film The Secret of NIMH when he was ten years old, and has since expanded his work extensively into animation and video games.

In the realm of anime, Wheaton is perhaps best recognized for his role as Yakumo in the 2009 series Kurokami The Animation. Yakumo is a secondary character in this action series produced by Sunrise, which aired simultaneously in Japan and North America. Wheaton voiced this character for the entirety of the show's run, contributing to an English voice cast that included noted performers such as Laura Bailey and Jason Griffith.

Wheaton also has multiple credits within the Naruto franchise, demonstrating a recurring presence in the popular long-running series. In the original Naruto anime, he voiced Menma, a kind-hearted former bandit who appears in a three-episode arc and ultimately sacrifices himself to save a village. Wheaton later returned to the franchise to voice two different characters in Naruto Shippuden. He played a Sand Messenger in an early episode of the television series and also voiced Taruho, a loyal bodyguard, in the Naruto Shippuden theatrical film. Wheaton has spoken positively about his experience working on Naruto, noting his enthusiasm for performing the genre's characteristic vocal expressions.

His additional anime voice credits include the role of Hans in The Slayers Evolution-R, the fourth season of the classic fantasy-comedy anime series, where he voiced a character in a single episode. Wheaton further contributed to the English dub of Mobile Suit Gundam Unicorn as Aaron Terzieff, adding a major entry in the iconic mecha franchise to his portfolio.

Wheaton's anime voice acting reflects a broader pattern of engagement with nerd culture and genre entertainment, complementing his extensive work in Western animation, video games, and audiobook narration. While his anime roles are not as numerous as his performances in American-produced cartoons such as Teen Titans and Ben 10, his recurring work in titles like Naruto and Kurokami demonstrates a sustained and enthusiastic participation in the field.