Jack De Sena is an American actor born John Patrick DeSena on December 6, 1987 in Boston, Massachusetts. He is known for his extensive work in voice acting, particularly in animated series with crossover appeal to anime audiences. De Sena began his entertainment career as a cast member on the Nickelodeon sketch comedy series All That from 2002 to 2005 before transitioning more prominently into voice work.

In the realm of anime and anime-influenced animation, De Sena is best recognized for his role as Sokka in the acclaimed series Avatar: The Last Airbender, which aired from 2005 to 2008. He also voices Prince Callum in The Dragon Prince, a fantasy series created by Avatar veterans that shares a similar stylistic and narrative approach. His other anime-related voice credits include the role of Rand in Generator Rex and Shiraa in the English dub of Doraemon: Nobita and the Green Giant Legend. More recently, De Sena joined the cast of the English dub for the mecha series Mobile Suit Gundam GQuuuuuuX, providing the voice for the character Jezzi.

De Sena has developed recurring professional collaborations within the animation industry. He has worked multiple times with director Giancarlo Volpe, who served as a director on Avatar: The Last Airbender and as a producer on The Dragon Prince. His consistent presence in projects associated with the Avatar creative team highlights a professional network that has shaped much of his voice acting career. Beyond his anime and genre voice work, De Sena has also appeared in live-action television series such as Sam & Cat and 100 Things to Do Before High School, and he has performed voice roles for DC animated films including JLA Adventures: Trapped in Time as Robin. Since 2016, he has collaborated with creative partner Chris W. Smith on comedy sketches for their YouTube channel Chris & Jack.