Setsuko Karasuma, also known as Setsuko Karasumaru, is a Japanese actress and voice actress born on February 3, 1955, in Shiga Prefecture, Japan. Her career began in 1980 when she debuted as a Clarion Girl and quickly transitioned into gravure idol work before making her film debut as the lead in the movie adaptation of Four Seasons Natsuko. Over the course of her career, she has balanced work in both live-action cinema and voice acting.

Karasuma's most prominent anime voice role is Momoko in the 1987 animated film Twilight of the Cockroaches. This film, which combines live-action and animation, features Karasuma providing the voice for the character, a neighbor cockroach. Beyond this notable role, she is primarily recognized as a live-action actress with an extensive filmography that includes Station, for which she received a nomination for Best Supporting Actress at the 5th Japan Academy Film Prize, and Four Seasons Natsuko, which earned her a nomination for Best Actress at the 4th Japan Academy Film Prize.

Her career spans several decades, with appearances in international productions such as Paul Schrader's Mishima: A Life in Four Chapters. Additional film credits include The Crimes That Bind, Ride or Die, and The Matsugane Potshot Affair. Information regarding recurring collaborations with specific animation directors, studios, or other voice actors is not available.