"Kero Kero Keroppi no Kero Kero House no Himitsu" centers around Keroppi, a cheerful and curious frog, and his friends as they uncover the mysteries surrounding Kero Kero House, a magical and seemingly ordinary home. The narrative begins with Keroppi and his close companions, including his twin siblings Koroppi and Pikki, discovering that Kero Kero House possesses hidden rooms and magical properties that respond to their emotions and actions. Each episode explores a new secret or challenge tied to the house, often involving puzzles, riddles, or magical phenomena that require teamwork and creativity to solve.

The main characters include Keroppi, who serves as the optimistic and resourceful leader; Koroppi and Pikki, who bring youthful energy and occasional mischief; and their friends, such as Den Den, a thoughtful and inventive turtle, and Ganta, a shy but loyal alligator. Together, they navigate the house’s ever-changing layout, encountering whimsical elements like talking furniture, enchanted objects, and portals to fantastical realms. The house itself acts as a character, guiding the group through its secrets while teaching them lessons about friendship, problem-solving, and self-discovery.

The plot unfolds episodically, with each adventure revealing more about the house’s origins and its connection to the characters. Themes of curiosity, cooperation, and perseverance are woven throughout, as the group works together to unlock the house’s mysteries and protect it from external threats. The series balances lighthearted humor with moments of suspense, creating an engaging and family-friendly narrative that appeals to a wide audience.