"Meitantei Holmes: Mrs. Hudson Hitojichi Jiken / Dover Kaikyō no Daikūchūsen!" is a two-part anime special that adapts elements from the Sherlock Holmes universe, reimagining the iconic detective and his companions as anthropomorphic animals. The story is set in a steampunk-inspired Victorian London, where Sherlock Holmes, a dog, and his loyal assistant, Dr. John Watson, a bear, solve intricate mysteries.

The narrative begins with Mrs. Hudson, Holmes's landlady, being kidnapped by a mysterious assailant. Holmes and Watson quickly deduce that the kidnapping is linked to a larger conspiracy involving a powerful airship and a plot to destabilize international relations. The duo embarks on a high-stakes investigation, uncovering clues that lead them to the Dover Strait, where a dramatic confrontation unfolds aboard the airship. The story intertwines elements of espionage, political intrigue, and classic detective work, as Holmes uses his sharp intellect and deductive reasoning to unravel the mystery and rescue Mrs. Hudson.

The main characters include Sherlock Holmes, portrayed as a brilliant and eccentric detective with a keen eye for detail; Dr. Watson, his steadfast and resourceful companion; and Mrs. Hudson, whose kidnapping serves as the catalyst for the adventure. The antagonists are a shadowy group of individuals with ties to the airship's operations, whose motives are gradually revealed as the plot progresses. The special blends action, suspense, and humor, staying true to the spirit of the original Sherlock Holmes stories while incorporating unique anime-inspired twists. The steampunk aesthetic and anthropomorphic character designs add a distinctive visual flair to the narrative, enhancing the adventurous tone of the story.