"Anime V Comic Rentaman" centers on the life of Rentaro Ichinose, a young man working as a "Rentaman," a professional who takes on odd jobs and tasks for clients. The series blends comedy, slice-of-life, and action elements, exploring Rentaro's daily challenges as he navigates his unconventional career. His work often leads him into bizarre and unpredictable situations, ranging from mundane errands to high-stakes missions, all while interacting with a colorful cast of characters.

Rentaro's clients include a mix of ordinary people and eccentric personalities, each with unique requests that test his adaptability and resourcefulness. The narrative frequently highlights the contrast between Rentaro's laid-back demeanor and the chaotic nature of his assignments. Supporting characters, such as his childhood friend and occasional partner, add depth to the story, providing both comedic relief and emotional moments.

The series also delves into Rentaro's personal growth, as he learns to balance his professional responsibilities with his own aspirations and relationships. Themes of perseverance, friendship, and self-discovery are woven into the episodic structure, with each job offering new insights into Rentaro's character and the world around him. The plot maintains a lighthearted tone while occasionally addressing more serious topics, creating a balanced narrative that appeals to a wide audience.