"Selector Infected WIXOSS" is a psychological anime series centered around the card game WIXOSS, which becomes a catalyst for intense personal struggles and supernatural phenomena. The narrative revolves around Ruko Kominato, a reserved high school girl who discovers a mysterious LRIG card named Tama in her deck. LRIGs are sentient cards that serve as avatars in the WIXOSS battles. Ruko learns that she has been chosen as a Selector, a player granted the chance to compete in special matches with the promise of having their greatest wish granted if they achieve three consecutive victories. However, the cost of losing is severe, as defeated Selectors lose their memories or suffer other irreversible consequences.

As Ruko delves deeper into the world of Selectors, she encounters other players, each driven by their own desires and emotional burdens. Yuzuki Kurebayashi, a classmate and fellow Selector, seeks to reconnect with her estranged brother, while Hitoe Uemura, a shy and kind-hearted girl, struggles with loneliness and the pressure of the battles. The series explores the psychological toll of the Selectors' choices, as their wishes often come at the expense of their humanity or relationships. Tama, Ruko's LRIG, is initially cheerful and naive but harbors a darker secret tied to the origins of the Selector battles.

The narrative takes a darker turn as the true nature of the Selector system is revealed. The LRIGs are revealed to be former humans trapped in card form, and the ultimate goal of the battles is to allow an LRIG to take over the body of their Selector, effectively erasing the original personality. This revelation forces Ruko and the other Selectors to confront the moral and existential dilemmas of their participation. The series examines themes of identity, desire, and the consequences of pursuing one's wishes at any cost, culminating in a tense and emotionally charged resolution that leaves lasting impacts on the characters.