The series centers on Opanchu Usagi, a creature living on Earth whose persistent efforts across various endeavors consistently fail to yield positive results. Her unrewarded struggles and the pitiful yet endearing quality of her failures have earned her the description of being pitifully cute, a trait that has resonated strongly with audiences. The narrative follows her daily life as she confronts one unfortunate situation after another.

Alongside Opanchu Usagi is Npochamu, a yogurt fairy who has a distinctive speech pattern, ending her sentences with the word chamu. Frequently finding herself entangled in trouble, Npochamu relies on her dependable best friend, Kimimaro, who is always ready to provide swift support whenever she needs it. This core trio forms the heart of the series, with their interactions and misadventures driving the comedy and emotional beats.

The setting is contemporary Earth, where these characters exist as creatures and beings in a familiar world, allowing their exaggerated misfortunes to feel both fantastical and relatable. The narrative arcs are primarily episodic, focusing on the characters as they take on new challenges or encounter everyday problems, only for things to go humorously and predictably wrong for Opanchu Usagi or for Npochamu to stumble into a predicament from which Kimimaro must rescue her. The overarching theme revolves around the charm of failure and the warmth of dependable friendship in the face of small-scale disasters. The series is produced as a 3D animated work, bringing these popular characters to life in a new visual format.