"World Fool News" is a comedic anime series that revolves around the fictional news program of the same name, which airs in the fictional city of Foolstown. The show parodies real-world news broadcasts, blending absurd humor with satirical commentary on media and society. The narrative centers on the eccentric staff of the news program, who deliver bizarre and often nonsensical reports on events that range from the mundane to the surreal. Each episode is structured as a series of news segments, featuring recurring segments like weather forecasts, investigative reports, and human-interest stories, all infused with exaggerated and absurd humor.

The main characters include the anchor, a straight-faced yet clueless host who delivers the news with unwavering seriousness despite its absurdity; the weather reporter, who often goes off-script and engages in bizarre antics; and a field reporter who frequently finds himself in ridiculous and dangerous situations while covering stories. The supporting cast includes various quirky individuals who contribute to the chaotic nature of the program, such as a director who prioritizes entertainment over accuracy and a production team that often struggles to keep the show on track.

The humor in "World Fool News" derives from its over-the-top portrayal of news media tropes, with each segment escalating in absurdity. The series frequently breaks the fourth wall, acknowledging its own ridiculousness and playing with the conventions of both news broadcasting and anime storytelling. The episodic structure allows for a wide variety of comedic scenarios, from parodies of political scandals to surreal encounters with supernatural phenomena. Despite its comedic tone, the series occasionally touches on themes of media sensationalism and the blurred line between reality and entertainment, though these elements are always presented in a lighthearted and exaggerated manner.