"Sci-Fi Harry" is a 20-episode anime series that blends science fiction, mystery, and psychological elements. The narrative centers on Harry MacKenzie, a high school student with a troubled past, who possesses telekinetic abilities. These powers, which allow him to manipulate objects with his mind, are tied to a mysterious organization known as the "Organization." This group conducts experiments on individuals with psychic abilities, and Harry becomes a target due to his unique potential.

The story unfolds as Harry transfers to a new school, where he encounters other students with psychic powers, including Rei Sagami, a girl with telepathic abilities, and Takeshi Todo, who can manipulate fire. Together, they navigate a world where their powers make them both targets and tools for the Organization. The series delves into the ethical implications of psychic experimentation, as well as the personal struggles of the characters as they grapple with their abilities and the consequences of using them.

As the plot progresses, Harry and his friends uncover the Organization's broader agenda, which involves harnessing psychic energy for global domination. The series explores themes of identity, morality, and the cost of power, as the characters are forced to confront their own fears and desires. The narrative builds toward a climactic confrontation between Harry and the Organization, culminating in a resolution that ties together the personal and overarching conflicts.

The main characters are developed through their interactions and individual arcs. Harry's journey is central, as he evolves from a reluctant and isolated figure to someone who embraces his role in the fight against the Organization. Rei and Takeshi provide emotional depth and camaraderie, each dealing with their own struggles related to their powers and pasts. The Organization's enigmatic leader, Dr. Kuroki, serves as the primary antagonist, embodying the cold, calculating nature of the experiments and the broader threat they pose.

"Sci-Fi Harry" balances episodic storytelling with an overarching plot, allowing for both character development and the gradual unveiling of the series' mysteries. The narrative maintains a steady pace, with tension building as the stakes escalate and the true extent of the Organization's plans is revealed. The series concludes with a resolution that addresses the central conflicts while leaving room for reflection on the themes explored throughout the story.