"The Duke of Death and His Maid" is a supernatural romance anime set in a Victorian-inspired world. The protagonist, a young nobleman known only as the Duke, is cursed by a witch during his childhood. The curse causes anything he touches to wither and die, leading to his exile from his family. He lives in a secluded mansion, isolated from society, with only a small group of servants for company. Among them is Alice, his devoted and flirtatious maid, who remains unfazed by his curse and frequently teases him with playful affection.

The Duke’s curse becomes the central conflict of the story, as he yearns for human connection but is constantly reminded of the danger he poses to others. Alice’s unwavering loyalty and affection for him create a bittersweet dynamic, as she openly expresses her love while he struggles with guilt and fear of harming her. The narrative explores their evolving relationship, blending moments of humor, tenderness, and melancholy.

Supporting characters include Rob, the Duke’s childhood friend and butler, who provides comic relief and emotional support, and Viola, the Duke’s younger sister, who occasionally visits the mansion. Viola’s visits often bring tension, as she harbors unresolved feelings about her brother’s exile and the family’s fractured relationships. The story also introduces other supernatural elements, including witches and magical beings, who play a role in the Duke’s quest to break his curse.

As the series progresses, the Duke and Alice uncover clues about the origins of the curse and the possibility of reversing it. Their journey intertwines with themes of love, sacrifice, and the struggle against fate, as they navigate the challenges posed by the curse and their growing feelings for each other. The narrative maintains a balance between lighthearted moments and emotional depth, creating a poignant exploration of love in the face of seemingly insurmountable obstacles.