"Neko de Yokereba" centers around a young man named Sōta Mizushina, who leads an ordinary life until a fateful encounter with a mysterious cat. After saving the cat from a dangerous situation, it transforms into a humanoid cat-girl named Neneko, who declares her intent to live with him as a form of gratitude. Neneko’s presence introduces a series of comedic and chaotic events, as her cat-like behavior and supernatural abilities disrupt Sōta’s daily routine. The narrative explores their evolving relationship, blending slice-of-life moments with lighthearted humor and occasional fantastical elements.

The story expands with the introduction of additional characters, each contributing to the dynamic of Sōta’s life. Neneko’s sister, Nyamsus, arrives later, bringing her own quirks and adding to the comedic tension. Other characters, such as Sōta’s childhood friend Chiya and a rival cat-girl named Kaho, further complicate the situation, creating a mix of romantic and competitive undertones. The interactions between these characters often revolve around misunderstandings, playful rivalries, and the challenges of balancing human and cat-like instincts.

Throughout the series, the plot maintains a focus on the humorous and heartwarming aspects of Sōta’s life as he navigates the peculiarities of living with cat-girls. The narrative avoids heavy drama, instead opting for a light-hearted tone that emphasizes the absurdity of the situations and the endearing qualities of the characters. The series concludes with a sense of resolution, as Sōta and the cat-girls find a harmonious balance in their unconventional living arrangement, leaving room for potential future developments.