"Condom Battler Goro" is a surreal and unconventional anime series that blends comedy, action, and social commentary. The story centers on Goro, a young man who discovers a unique ability to transform condoms into powerful weapons. This ability is tied to a mysterious organization that recruits individuals to combat a growing threat posed by sexually transmitted infections (STIs) personified as monstrous entities. These entities, known as "STI Demons," wreak havoc by spreading disease and chaos, and Goro is tasked with using his condom-based arsenal to protect humanity.

The narrative unfolds as Goro joins a team of similarly gifted individuals, each wielding their own specialized condom-based weaponry. The team operates under the guidance of a secretive leader who provides them with missions to track down and eliminate STI Demons. As the series progresses, Goro and his teammates face increasingly dangerous foes, requiring them to refine their skills and develop new strategies. The battles are often exaggerated and comedic, with the condom weapons taking on absurd and imaginative forms, such as whips, shields, and even projectiles.

Throughout the series, Goro grapples with the responsibility of his newfound role while navigating the challenges of teamwork and personal growth. The story also explores themes of sexual health, responsibility, and the consequences of ignorance, using its fantastical premise to deliver messages about safe practices and awareness. Supporting characters, including Goro's teammates and the enigmatic leader, contribute to the narrative with their own backstories and motivations, adding depth to the overarching plot.

The tone of the series balances humor with moments of tension and drama, creating a unique blend of genres. While the premise is inherently absurd, the anime takes its internal logic seriously, maintaining a consistent narrative structure. The episodic format allows for a variety of encounters with STI Demons, each presenting distinct challenges and requiring creative solutions. As the story progresses, a larger conspiracy involving the origins of the STI Demons and the true purpose of Goro's organization is gradually revealed, culminating in a climactic confrontation that tests the limits of the team's abilities and resolve.