"Keifuku-san" is a short-form anime series that revolves around the daily life of Keifuku, a young girl who works as a shrine maiden at a local Shinto shrine. The narrative is episodic, focusing on her interactions with the shrine's visitors, her fellow shrine maidens, and the various deities and spirits associated with the shrine. Keifuku is portrayed as diligent and earnest, often going out of her way to assist those who come to the shrine, whether they are seeking blessings, guidance, or simply a place of solace.

The shrine itself serves as the central setting, with its serene atmosphere contrasting with the occasional comedic or supernatural events that occur. Keifuku's duties range from performing traditional rituals to dealing with mischievous spirits that occasionally cause trouble. Her interactions with the spirits are often lighthearted, showcasing her patience and resourcefulness in resolving their antics.

Supporting characters include other shrine maidens who share Keifuku's responsibilities, each with distinct personalities that contribute to the dynamics of their teamwork. The deities and spirits, while sometimes playful or troublesome, are depicted with a sense of reverence, reflecting the cultural and spiritual significance of the shrine. The series balances moments of humor with a respectful portrayal of Shinto traditions, offering a glimpse into the daily life of a shrine maiden and the spiritual world she inhabits.

The episodic structure allows for a variety of scenarios, from mundane tasks like cleaning the shrine grounds to more extraordinary encounters with supernatural beings. Despite the occasional fantastical elements, the series maintains a grounded tone, emphasizing the importance of community, tradition, and the small joys of everyday life. Through Keifuku's experiences, the series provides a gentle exploration of spirituality, duty, and the connections between humans and the divine.