"Tanuki to Kitsune" centers on the lives of two yokai, a tanuki named Tanukichi and a kitsune named Kitsuko, who coexist in a rural Japanese village. The narrative explores their daily struggles and adventures as they navigate the complexities of living among humans while preserving their yokai identities. Tanukichi, a mischievous yet good-natured tanuki, often uses his shape-shifting abilities to play pranks on villagers, while Kitsuko, a more reserved and cunning kitsune, employs her intelligence and magical prowess to solve problems and protect their community.

The story unfolds as the village faces external threats, including human encroachment and the arrival of malevolent spirits. Tanukichi and Kitsuko must work together to defend their home, often clashing due to their differing personalities and approaches. Tanukichi’s impulsiveness and Kitsuko’s calculated strategies create a dynamic interplay that drives much of the plot. Their relationship evolves from rivalry to mutual respect as they confront challenges that test their abilities and bond.

Supporting characters include a wise old tengu who serves as a mentor, a human villager who unknowingly befriends the yokai, and other yokai with unique traits and roles in the village. The series balances episodic adventures with an overarching narrative, blending humor, folklore, and moments of tension. Themes of coexistence, identity, and the preservation of tradition are woven into the story, reflecting the cultural significance of yokai in Japanese folklore. The interplay between the supernatural and human worlds is a recurring motif, highlighting the delicate balance between secrecy and integration.