"Dirty by the Dozen" centers on a group of twelve individuals, each with distinct personalities and backgrounds, who are thrust into a high-stakes survival scenario. The narrative unfolds in a dystopian setting where societal collapse has led to widespread chaos. The group, initially strangers, is forced to band together after being targeted by a powerful and enigmatic organization. This organization, known only as "The Syndicate," seeks to eliminate them for reasons initially unclear, though hints suggest their unique skills or past actions have made them threats.

The story is structured around their journey to uncover the truth behind The Syndicate's motives while evading relentless pursuers. Each character brings a specific skill set to the group, ranging from combat expertise to technological proficiency, which becomes crucial as they navigate a series of increasingly dangerous challenges. The dynamics within the group are a focal point, with alliances, rivalries, and personal histories influencing their interactions and decisions.

Key characters include Kaito, a former soldier with a stoic demeanor and a mysterious past; Aiko, a hacker with a sharp wit and a penchant for uncovering secrets; and Ren, a charismatic but morally ambiguous leader who often clashes with Kaito over the group's direction. Other members, such as Yuna, a medic with a tragic backstory, and Haruto, a skilled engineer, contribute to the group's survival in unique ways.

As the series progresses, flashbacks and episodic storytelling reveal the individual histories of the characters, shedding light on their motivations and the events that led to their current predicament. The plot thickens as they discover that The Syndicate's interest in them is tied to a larger conspiracy involving government corruption, experimental technology, and a hidden agenda that could reshape the world.

The narrative balances action-packed sequences with moments of introspection, exploring themes of trust, sacrifice, and the cost of survival. The group's journey is marked by both victories and losses, with each encounter bringing them closer to the truth while testing their resolve. The series concludes with a climactic confrontation that leaves some questions unanswered, setting the stage for potential future developments.