"Licca-chan no Nichiyōbi" is a 26-episode anime series that centers around Licca Kayama, an 11-year-old girl navigating the challenges of school, friendships, and family life. The narrative unfolds in a slice-of-life format, capturing the everyday experiences and emotions of Licca and her peers. Licca lives with her parents and younger brother, Masaru, in a modest household. Her father, a manga artist, and her mother, a homemaker, provide a supportive yet occasionally chaotic environment that mirrors the ups and downs of family dynamics.

The series explores Licca's relationships with her classmates, particularly her close friends Mariko and Miho. Together, they face typical pre-adolescent dilemmas, such as school projects, crushes, and misunderstandings. Licca often finds herself in situations where she must balance her responsibilities, such as helping her father with his work or caring for her brother, with her desire to enjoy her childhood. These moments highlight her resourcefulness and kindness, as she frequently goes out of her way to help others, even when it complicates her own life.

A recurring theme is Licca's aspiration to become a fashion designer, which is reflected in her creative outfits and imaginative ideas. This dream is occasionally challenged by her insecurities and the pressures of growing up, but it also serves as a source of motivation. The series also delves into the lives of secondary characters, such as Licca's teacher, Miss Yumi, and her classmates, who each bring their own struggles and triumphs to the story. These subplots enrich the narrative, providing a broader perspective on the challenges and joys of childhood.

The tone of the series is lighthearted and heartwarming, with occasional moments of drama that underscore the emotional growth of the characters. Episodes often conclude with a moral or lesson, emphasizing values such as honesty, perseverance, and empathy. The setting, a typical Japanese town, is depicted with a sense of familiarity and warmth, grounding the story in a relatable reality. Through its focus on everyday experiences and relatable characters, "Licca-chan no Nichiyōbi" offers a thoughtful portrayal of childhood and the importance of family and friendship.