Misuzu-Sensei is a supporting character in the anime Nurse Witch Komugi-chan R. She serves as the homeroom teacher for the protagonists Komugi Yoshida and Kokona Saionji, as well as their classmates. Physically, she is an adult woman with short purple hair that reaches her ears and orange eyes. She is often seen wearing a tracksuit, arm bands, sneakers, and a whistle, which reflects her active and disciplinarian approach to teaching.

Her most distinctive trait is her use of professional wrestling moves on students who arrive late to class, particularly Komugi. This harsh disciplinary style is presented comically, but it is consistently shown that her sternness comes from a place of genuine concern. Despite her rough treatment of the students, Misuzu-Sensei cares deeply for their well-being and is willing to go to great lengths to protect them. Her motivations are rooted in a desire to see her students succeed and stay safe, even if her methods are unorthodox.

Throughout the series, her role remains that of a strict but caring authority figure who provides comic relief through her wrestling antics while also offering moments of support for her students. By the end of the series, she achieves a remarkable personal milestone: she becomes the first homeroom teacher ever to successfully become a professional wrestler, a culmination of her signature fighting style and dedication. This development highlights her unique blend of educator and athlete, and it underscores the series' playful tone. Her key relationships are with Komugi and Kokona, whose lateness and antics often trigger her disciplinary actions, and with the broader student body whom she protects. While not a main character, Misuzu-Sensei stands out for her memorable blend of toughness and hidden warmth. Her notable ability is her proficiency in a variety of pro-wrestling techniques, which she uses both as a teaching tool and later as a professional sport.