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Kotetsu Serizawa held high-ranking positions within the Earth Defense Force, serving as Far-East District military bureau director and later rising to Deputy Commander of the United Nations Cosmo Force, subsequently known as the Earth Federation Cosmo Force. His decisions profoundly influenced Earth's interstellar conflicts and policies.

In 2191, as military director, Serizawa ordered an unprovoked attack on an alien fleet near Pluto, overriding Admiral Juzo Okita's objections. This first contact incident, falsely reported as alien aggression, ignited the devastating Garmillas War. Survivors received a gag order to suppress the truth. During the war's desperate phase, Serizawa spearheaded Project Izumo, a plan to evacuate humanity to a new planet. After Program Yamato superseded Izumo, he secretly continued Izumo preparations, fabricating records and embedding loyal personnel aboard Yamato to execute his plan. He authorized Lieutenant Kaoru Niimi to initiate a mutiny to divert Yamato from its Iscandar mission; the mutiny failed.

Following the war's end via a treaty banning wave motion weaponry, Serizawa, as Deputy Commander, actively supported violating this agreement. He oversaw the construction of warships equipped with wave motion guns, such as the Andromeda-class battleships. During the Gatlantis conflict, he advocated deploying these weapons, justifying their use to Garmillas ambassador Loren Burrell by asserting Admiral Okita lacked the authority to negotiate for Earth. He monitored Yamato's crew for dissent, ordering a military satellite attack when they departed without authorization, fearing widespread mutiny. He later refused to court-martial defector Saburo Kato to protect morale.

After the Gatlantis Campaign, Serizawa opposed sacrificing the critical time fault technology to rescue stranded Yamato officers Susumu Kodai and Yuki Mori, arguing it was essential for Earth's rebuilding. During a referendum on the issue, he publicly supported retaining the fault but privately voted for the rescue and confessed envy for the crew's idealism. He later wept witnessing the successful rescue operation.

By 2205, as Deputy Commander-in-Chief of the Earth Federation Defense Force, Serizawa transitioned to advocating peace. He promoted Earth as a reborn peaceful nation and joined a diplomatic delegation to Garmillas and Iscandar as Earth's plenipotentiary ambassador, focusing on preventing interstellar conflicts from reaching Earth.