Misato Yotsuba is a supporting human character in the anime Kami-sama Minarai: Himitsu no Cocotama. Originally bearing the maiden name Misato Yachigusa, she is the daughter of Akio Yachigusa and Haruko Yachigusa. She later marries Koichi Yotsuba and becomes the mother of two children, the protagonist Kokoro Yotsuba and her younger brother Makoto Yotsuba. In the story, Misato is a working mother who owns and operates a knitting and fabric store in Aozora Town, demonstrating her industrious and hands-on nature.

Misato is portrayed as a kind, caring, and nurturing parental figure. She is supportive of her family and maintains a warm household. Her background as a craft shop owner ties into the series' emphasis on treasuring objects, as she works in an environment centered on handmade goods and materials. Her motivations revolve around providing for her family and fostering a loving home. Her role in the story is primarily that of a supportive mother, providing a stable backdrop for Kokoro's adventures with the Cocotama. While she is unaware of the Cocotama's existence, one of these small gods, Kirarise, was born from a treasured lipstick that Misato used, indicating the depth of care she puts into her personal belongings. Her key relationships are with her husband Koichi, her daughter Kokoro, and her son Makoto, with whom she shares a close and affectionate bond. She does not undergo major personal development in the series but functions as a consistent source of warmth and stability. She does not possess any supernatural abilities; her notable traits are her practical skills in sewing and knitting, as well as her gentle and dependable presence within the Yotsuba household.