Naoko Isami is the matriarch of the Isami household, a role rooted in her history as a former university researcher who once studied the mysterious entity known as Orphan alongside her research partner and later lover, Winston Geybridge. When Geybridge departed for America, she married a fellow researcher named Isamu, but he died while investigating a fissure in the earth shortly after the birth of their daughter, Midori. Widowed and left to care for her family, Naoko became the emotional anchor of the household. She raised her grandchildren, Yuu and Quincy, when their parents Kensaku and Midori became consumed by their work inside Orphan and began using the children as initial test subjects for piloting the organic Antibody mecha called Grand Cher. Naoko deeply resents this exploitation, yet she does not allow her bitterness to consume her; instead, she offers Yuu the wisdom and warmth he lacks from his parents, helping him develop his own moral compass. Her personality is defined by a quiet resilience, a caring and loving nature, and a clear-eyed understanding of right and wrong. She lives in a village above the ocean, tending a tomato patch that becomes a symbolic safe haven for the younger characters. Her key relationships include her affectionate bond with Yuu, her complicated but still loyal connection to Winston Geybridge, and her protective stance toward Quincy and the other young pilots who come into her orbit. Upon reuniting with Geybridge aboard the warship Novis Noah, she rekindles the romantic feelings she had set aside decades earlier, a development that gives her a renewed sense of purpose in the larger conflict. Naoko does not pilot a mecha or possess any supernatural abilities; her strength lies in her steadiness, her insight, and her ability to offer a peaceful, grounded perspective in a story of apocalyptic upheaval. Over the course of the series, she grows from a figure of domestic stability into someone who actively aids the Novis Noah crew, most notably by introducing the protagonists Hime and Yuu to Geybridge and thereby facilitating crucial alliances. Her arc is one of reconciliation: with her old love, with her family's painful history, and with her own role in helping shape a better future.