"Brain Powered" is a 26-episode mecha anime series set in a future where humanity faces environmental collapse and societal upheaval. The story revolves around the conflict between two factions: the Orbital Frame, a technologically advanced organization seeking to preserve humanity by relocating it to a new habitat called "Second Earth," and the Gards-orm, a mysterious, organic life form that opposes this plan. The central narrative explores themes of survival, evolution, and the ethical dilemmas surrounding humanity's future.

The protagonist, Yuu Isami, is a young man who becomes involved in the conflict after encountering the Brain Powerd, a group of biomechanical mecha powered by the mysterious energy source known as "Orphan." Yuu pilots one of these mecha, named "Noevir," and struggles with his role in the war while grappling with personal trauma and a fractured relationship with his mother, Kyo Isami, who leads the Orbital Frame. Kyo's vision for humanity's future clashes with Yuu's growing doubts about the morality of abandoning Earth and the consequences of relying on Orphan.

The series introduces a diverse cast of characters, including Hime Utsumiya, a determined and compassionate pilot who forms a close bond with Yuu, and Jonathan Glenn, a scientist working with the Orbital Frame who harbors his own secrets. As the story progresses, the true nature of the Gards-orm and Orphan is revealed, raising questions about the balance between technological progress and natural evolution. The narrative builds toward a climactic confrontation that forces the characters to confront their beliefs and the potential consequences of their actions.

"Brain Powered" blends mecha action with philosophical undertones, exploring the tension between humanity's desire for advancement and its connection to the natural world. The series presents a complex web of relationships, moral ambiguity, and the struggle to define what it means to preserve humanity in the face of existential threats.