Misa Ichijō is a Best representing the Kamogawa Rockers in Kyoto, a role that makes her a superpowered combatant in the territorial disputes of a post-apocalyptic Japan divided into independent city-states. She serves as the leader of her vigilante group, which operates within Kyoto's traditional cultural landscape while engaging in high-stakes conflicts. Her appearance is striking, with long gray hair that reaches her hips and pinkish-purple eyes, and in everyday settings she is sometimes depicted with long black hair and glasses, giving her a cool and mysterious demeanor. At the core of her identity is her past as a rock musician. She uses a heart-shaped stone attached to a bracelet as a guitar pick, a signature item that connects her power as a Best to her musical background. This stone also serves as a weapon when she wields her guitar in combat.

Misa's personality balances a stoic, authoritative exterior with significant emotional depth. She is driven by a sense of duty and responsibility as a leader, often prioritizing the expectations placed on her by her role and her family. Her motivations are rooted in a conflict between personal passion and societal pressure. She was once part of a musical partnership with Mamechiyo, a fellow musician who later becomes the leader of the maiko faction in Kyoto. Their relationship fractured due to external pressures, personal conflicts, and the influence of Misa's mother, who discouraged her from pursuing a path that might lead Mamechiyo astray. This past tension creates a deep-seated rivalry that the main characters must navigate when they arrive in Kyoto.

Throughout her arc, Misa develops from a tradition-bound leader who suppresses her true feelings into someone who openly embraces her love for music. The climax of her story occurs when she reconciles with Mamechiyo through an emotional duet that blends electric guitar and shamisen, allowing both characters to reconnect with their shared passion. This resolution marks a cathartic release and represents her growth beyond the rigid expectations that once defined her life. Her abilities as a Best include enhanced combat prowess, and she is a skilled guitarist who can turn her instrument into a weapon. She also demonstrates strong leadership and tactical acumen in maintaining order within her prefecture. Her journey illustrates the struggle to balance personal identity with the responsibilities imposed by a fractured society, making her a memorable character within the series.