Henry Stafford, Duke of Buckingham, is a nobleman marked by significant ambition and political cunning. He becomes a key ally to Richard III, supporting Richard's ascent to the throne by orchestrating the purge of the Woodville family and other adversaries. Buckingham's initial loyalty stems from his recognition of mutual ambition with Richard, both consolidating power within the House of York.

A complex personal relationship develops between Buckingham and Richard, evolving from political partnership to romantic involvement. Buckingham learns Richard's secret of being intersex and accepts this aspect, fostering a deeper bond. Their connection includes intimate moments, such as Richard finding comfort sleeping with Buckingham's coat, forming a central element of Buckingham's character arc.

A pivotal turning point occurs when Buckingham impregnates Richard. Richard's adamant refusal to carry the pregnancy causes Buckingham to feel betrayed and rejected. This personal conflict fuels Buckingham's disillusionment, prompting his shift from ally to antagonist. His resentment drives him to orchestrate a rebellion against Richard's rule.

Buckingham's rebellion fails due to natural obstacles like flooded rivers stalling his army and betrayal by his retainer, Ralph Bannister. Captured, Buckingham faces execution ordered by Richard without a final meeting. He is beheaded in Salisbury, concluding his arc.

Throughout his story, Buckingham's actions are primarily motivated by personal ambition and a desire for power, though his relationship with Richard adds layers of emotional conflict. His trajectory charts a fall from influence driven by political miscalculation and personal grievances against Richard.