TV-Series
Description
Eisuke Hondou is a supporting character who becomes a student at Teitan High School, attending the same class as Ran Mouri and Sonoko Suzuki. He is seventeen years old and first appears while searching for his missing older sister, Hidemi, from whom he was separated during childhood. Eisuke is the son of Ethan Hondou, a deceased Central Intelligence Agency operative, and his sister is also a CIA agent working undercover within the Black Organization. As a child, Eisuke suffered from leukemia and received a bone marrow transplant from his sister, a procedure that changed his blood type from O to AB without his knowledge. He lived with his mother until her death from illness and later with his father in Osaka before his father left to resume undercover work and subsequently died to protect Hidemi's identity.

In terms of personality, Eisuke is consistently portrayed as extremely clumsy and unlucky, frequently tripping or bumping into objects. Despite this outward awkwardness, he possesses a sharp intellect and keen observational skills. He is generally jovial and friendly in his interactions, but he can also be very emotional, often letting his feelings get the better of him, especially in stressful situations.

Eisuke's primary motivation throughout his appearance in the story is the search for his sister, Hidemi. He transfers to Teitan High School after seeing a news anchor, Rena Mizunashi, who bears a striking resemblance to his missing sister. He becomes convinced that Mizunashi is connected to Hidemi's disappearance and investigates Kogoro Mouri, believing the detective might be hiding her. His role in the narrative becomes pivotal during the Clash of Red and Black arc, where his persistent investigation leads him to infiltrate the hospital where the Federal Bureau of Investigation is secretly holding the comatose Mizunashi. His confrontation with her forces the revelation that Rena Mizunashi is indeed his sister, Hidemi Hondou, an undercover CIA agent. After learning the truth about his family's espionage work, Eisuke refuses an offer to enter the Witness Protection Program. Instead, he resolves to follow in his father and sister's footsteps, leaving for the United States with the goal of joining the CIA.

His key relationships are central to his character. His bond with his sister, Hidemi, is the driving force of his actions; he remembers her as his protector who saved his life, and his search for her is relentless. He develops a close friendship with Ran Mouri, and he confesses that he has fallen in love with her. His most significant relationship is with Conan Edogawa. Eisuke grows highly suspicious of Conan, noticing the boy's unusual presence at crime scenes and deducing that he is the true mastermind behind the Sleeping Kogoro phenomenon. He ultimately figures out that Conan is actually Shinichi Kudo, confronting him and securing Conan's direct confession. After obtaining this confirmation, Eisuke promises to keep Conan's secret and asks him to take care of Ran, demonstrating his integrity and respect for their shared secret.

Regarding development, Eisuke evolves from an apparently clumsy and somewhat naive transfer student into a determined young man who uncovers a massive conspiracy involving international espionage. He transitions from a passive seeker of his sister to an active participant in the larger conflict, choosing to embrace the dangerous legacy his parents left behind. His emotional growth is shown as he comes to terms with the truth about his family, accepts his sister's dangerous double life, and makes the mature decision to leave his old life in Japan to pursue a career in intelligence.

Eisuke possesses several notable abilities that contrast sharply with his clumsy demeanor. He has sharp deductive reasoning and keen powers of observation, enabling him to track his sister to a secure hospital and deduce Conan Edogawa's true identity from subtle clues. He knows a specific lie detection technique involving monitoring a person's pulse and pupils, a method he learned from his father and which his sister also uses, hinting at their CIA training. His earlier ignorance about his blood type changing due to the bone marrow transplant is also a key plot point, as his mistaken belief that his type O blood would be incompatible with his sister's type AB was the primary reason he refused to believe that Rena Mizunashi could be Hidemi.