Mikan Tsumiki holds the title of Ultimate Nurse, also known as Super High School Level Health Committee Member, signifying her exceptional medical skills. Her appearance features long, unevenly cut dark purple hair and a beauty mark beneath her left eye. She typically wears a nurse uniform: a pale pink shirt, white apron, and blue pleated skirt. Bandages wrap her left arm and right leg, with a band-aid on her left knee. At Hope's Peak Academy, she wore the standard uniform, still displaying these bandages. Her childhood involved severe physical, emotional, and implied sexual abuse inflicted by family and school bullies. Specific torments included beatings, being smeared with mud, cigarette burns, forced stripping, eating bugs, animal imitation, and serving as a target for darts. This history resulted in chronic low self-esteem, extreme fear of abandonment, and a belief that mistreatment was preferable to being ignored. Lacking care for her injuries, she learned self-treatment and pursued nursing to gain control over vulnerable individuals, perceiving their dependence as power. Her personality exhibits chronic apologizing, stuttering, and tearfulness stemming from anxiety about offending others. She displays hyper-awareness of facial expressions, frequently misinterpreting neutral reactions as disdain. Pronounced clumsiness often causes embarrassing falls, sometimes perceived as attention-seeking. She forms pathological attachments to those showing kindness, like Hajime Hinata, and displays obsessive tendencies, including covertly watching others and fixating on medical tools such as syringes. A suppressed violent streak surfaces in her non-despair state, manifesting in outbursts about understanding murderous urges and an enjoyment of horror media's depictions of suffering. During her time in Hope's Peak Academy's Class 77-B, she was abducted by Junko Enoshima and Mukuro Ikusaba. Exposed to an experimental video containing subliminal messages, she became the first Remnant of Despair. She developed fanatical devotion to Junko, whom she termed "beloved," viewing her as the sole person who accepted her existence. As a Remnant, she manipulated classmates into despair and allegedly implanted Junko's womb into herself to bear her child. Within the Neo World Program simulation, her initial personality resurfaced due to memory suppression. Contracting the Despair Disease in Chapter 3 restored her memories, triggering a reversion to her despair state. She murdered Ibuki Mioda and Hiyoko Saionji to "reciprocate" Junko's love, later displaying unremorseful, manipulative behavior during the trial. Post-execution within the simulation, her physical body entered a coma. In the Hope Arc, she awakened from the coma with her original personality restored and Junko's brainwashing undone. She assisted her rehabilitated classmates in halting Ryota Mitarai's global brainwashing broadcast. Expressing guilt for her actions as a Remnant, she committed to atonement alongside Class 77-B. A notable act involved healing Kyoko Kirigiri using medical knowledge provided by a deceased Future Foundation member. Trivia notes her birthday as May 12 (coinciding with International Nurses' Day), height as 163 cm, and blood type A. She favors the smell of isopropanol and dislikes oversized objects.