Professor Sycamore responds to a medical emergency involving Mairin's Chespin, Chespie, rushing to Lysandre Labs after learning the Pokémon fell unconscious following exposure to an unknown energy source during an encounter with a mysterious green, cell-like creature. He attempts to comfort the distraught Mairin while observing the medical evaluation alongside Nurse Joy and others. Nurse Joy confirms Chespie has no physical injuries but remains comatose for undetermined reasons. Sycamore reassures Mairin of Chespie's physical stability despite the unresolved cause of its unconsciousness. When Lysandre intervenes, promising to keep Chespie at Lysandre Labs for advanced treatment using the facility's resources, Sycamore does not oppose the arrangement. His presence fades from focus as the narrative shifts to Lysandre's commitment to finding a cure and Alain's departure on a related mission. Sycamore's involvement is supportive and reactive, centered on his concern for Mairin and Chespie during the crisis, concluding without direct participation in primary battles or further investigation into the mysterious creatures.