Sayla Mass appears in the parody series "Mobile Suit Gundam-san" as a comedic reinterpretation of her original character. She hosts the recurring segment "Dr. Sayla's Consultation Room," offering exaggerated medical advice to the White Base crew in a clinical setting, referencing her original background as a medical student.

Her interactions feature physical comedy, notably administering disciplinary slaps to crew members like Kai Shiden. She visibly enjoys these violent outbursts, contrasting her typically composed demeanor. The consultation room includes an "anonymity screen" intended for patient privacy, but it fails as a running gag as characters remain easily identifiable.

The character design employs exaggerated physical proportions for comedic effect, with scenes emphasizing bodily attributes through slapstick. One episode centers on her ecstatic reaction to hitting Kai, escalating into exclamations that highlight the series' absurd tone. Her relationship with Amuro Ray includes instances where she physically assaults him for inappropriate behavior, such as his failed attempt to trigger a "funbag airbag" scenario during an escape.

Unlike her original counterpart, this parody version does not explore her heritage as Artesia Som Deikun or her familial ties to Char Aznable. Character dynamics are simplified solely for comedic purposes, with no references to political conflicts or wartime trauma. The focus remains exclusively on her exaggerated role as a medical authority figure prone to violent outbursts and situational humor.