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Originally named La Andromeda Promethium, she began as Yayoi Yukino, the Millennial Queen from the planet La Metal. Arriving on Earth as an infant, she was adopted by an elderly couple. Her time on Earth fostered deep human connections through work at an observatory and relationships with colleagues. This compassion and attachment led her to rebel against her biological mother Larela's plan to enslave humanity, choosing instead to protect Earth while maintaining ties to La Metal's colonists. After defeating Larela in a duel, Yayoi returned to La Metal to address its environmental crises, ruling peacefully for an extended period.

Facing La Metal's deteriorating artificial sun, Promethium initiated a mechanization program to preserve her civilization. She collaborated with her husband Dr. Ban, though their daughters Maetel and Emeraldas opposed it. During her own mechanization procedure, scientist Hardgear interfered, corrupting the process. This transformed Promethium from a benevolent ruler into a cold, machine-dominated entity. Before losing her free will, she sent her daughters away aboard the Galaxy Express 999. She later assimilated Hardgear, consolidating power to become an absolute tyrant who enforced mechanization across her empire.

As ruler of the Machine Empire, Promethium adopted a fanatical belief in mechanical superiority, viewing organic life with contempt. She enforced a hive-mind network to monitor citizens and suppress dissent, requiring constant energy from living beings converted into "Living Screws." Her appearance evolved into a pale, Noh mask-like visage, often shrouded in a dark veil with cosmic patterns. She wore a crown featuring heart-shaped ornaments that later transformed into gears. She retained a complex obsession with her daughter Maetel, implanting surveillance devices to share thoughts and emotions while attempting to recruit her as a successor, showing no genuine warmth.

Promethium wielded extensive technological control, including soul manipulation via "Soul Rings" to reprogram subjects into loyal servants and project planetary-scale holograms. She could convert humans into energy sources through lightning-based transmutation and create android duplicates of allies and enemies. Her centralized authority allowed command over all Machine Empire systems, though overconfidence in these systems became a critical vulnerability. She established new bases like the Great Mother Planet after initial defeats, demonstrating regenerative capabilities by transferring her consciousness into new mechanical bodies.

Her downfall resulted from multiple confrontations. On La Metal, human rebels and her daughters disrupted her energy supply, temporarily disintegrating her form. She resurfaced on Planet Promethium, where the sacrifice of a boy named Nazca only deactivated her temporarily. In the conflict depicted in *Adieu Galaxy Express 999*, Maetel feigned alliance to lure Tetsuro Hoshino as a replacement energy source. When Tetsuro resisted, Maetel used Dr. Ban's consciousness capsule—preserved since the initial mechanization—to trigger an overload, destroying her planetary body and backup systems, permanently ending her reign.