Ana Coppola is an 11-year-old British girl from Cornwall, England, who moved to Japan during kindergarten. Her blonde hair, blue eyes, and pale skin make her self-conscious among her predominantly dark-haired classmates. Her family lives in a large, wealthy Japanese home featuring a lawn and an elaborate gate buzzer.

Despite her foreign background, Ana possesses deep knowledge of Japanese culture, including folklore and complex kanji, and speaks exceptionally polite Japanese. Initially, she conceals this fluency, introducing herself only in simple English. This deception unravels when Matsuri Sakuragi overhears her speaking Japanese fluently, prompting Ana to drop the act. She subsequently forms friendships with Matsuri, Chika Itoh, and Miu Matsuoka. Ana feels discomfort about her surname "Coppola," especially when Miu teases her by comparing it to a psychomime and writing it with the kanji for "hole," "bone," and "cave."

Ana exhibits a sophisticated, well-mannered personality and refined fashion sense. She dislikes broccoli and tomatoes but enjoys Chika Itoh's cookies. Her pet dog is named Frusciante, after Red Hot Chili Peppers guitarist John Frusciante; Miu often calls him "Fu-chan." Ana navigates a cultural duality: she feels alienated by stares due to her appearance yet is deeply assimilated into Japanese customs, sometimes hiding her knowledge to avoid standing out. Nobue Itoh considers her the most adorable in the group.

In the *Strawberry Marshmallow Encore* OVA, Ana participates in group activities like Miu's imagined journey between heaven and hell, independent study sessions, and responding to prank calls. Her relationships remain consistent: a close bond with Matsuri, tolerance of Miu's antics and frequent teasing, and engagement in everyday adventures with the group. She maintains her established traits of politeness, occasional shyness, and cultural adaptability throughout.