Demogorgon appears as an antagonist in the *Shin Megami Tensei: DeviChil* anime adaptation. Serving directly under primary antagonist Zebul during the series' second half, this muscle-bound demon embodies a "brawn over brain" philosophy, prioritizing raw physical strength over intellectual strategy. He operates alongside fellow demons Vibhishana and Paimon within Zebul's forces. His role culminates in Zebul eliminating him near the series' conclusion, solidifying his position as a secondary antagonist whose actions support the main villain's objectives.

Within the *Devil Children* game series, specifically *Black Book* and *Red Book*, Demogorgon serves the demon Elegy, fighting on her behalf. After the player collects 150 demons in *Red Book*, Demogorgon becomes obtainable as an ally. As a boss demon, he possesses distinct combat capabilities. His skills include Agilao (dealing heavy fire damage to a single foe), Dark Spear (inflicting damage equal to one-third of the target's current HP), and Hell Thrust (causing medium damage that inflicts Mute status and ignores Guard defenses). Statistically, he is a level 26 General-type demon of the Moon race, noted for significant HP and MP reserves.